Laura Machesky - Publications

Affiliations: 
Beatson Institute for Cancer Research 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Machesky LM. CYRI proteins: controllers of actin dynamics in the cellular 'eat vs walk' decision. Biochemical Society Transactions. PMID 36892409 DOI: 10.1042/BST20221354  0.406
2022 Papalazarou V, Drew J, Juin A, Spence HJ, Whitelaw J, Nixon C, Salmeron-Sanchez M, Machesky LM. Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of Cell Science. 135. PMID 36546396 DOI: 10.1242/jcs.259978  0.363
2021 Olson MF, Machesky LM. MICAL2 fine-tunes Arp2/3 for actin branching. The Journal of Cell Biology. 220. PMID 34264264 DOI: 10.1083/jcb.202106176  0.311
2021 Le AH, Yelland T, Paul NR, Fort L, Nikolaou S, Ismail S, Machesky LM. CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. The Journal of Cell Biology. 220. PMID 34165494 DOI: 10.1083/jcb.202012114  0.442
2021 Drew J, Machesky LM. The liver metastatic niche: modelling the extracellular matrix in metastasis. Disease Models & Mechanisms. 14. PMID 33973625 DOI: 10.1242/dmm.048801  0.415
2020 Papalazarou V, Swaminathan K, Jaber-Hijazi F, Spence H, Lahmann I, Nixon C, Salmeron-Sanchez M, Arnold HH, Rottner K, Machesky LM. The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts. Development (Cambridge, England). PMID 33028610 DOI: 10.1242/dev.194555  0.395
2020 Papalazarou V, Machesky LM. The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces. Current Opinion in Cell Biology. 68: 37-44. PMID 32977244 DOI: 10.1016/j.ceb.2020.08.012  0.392
2020 Tweedy L, Thomason PA, Paschke PI, Martin K, Machesky LM, Zagnoni M, Insall RH. Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown. Science (New York, N.Y.). 369. PMID 32855311 DOI: 10.1126/Science.Aay9792  0.448
2020 Papalazarou V, Zhang T, Paul NR, Juin A, Cantini M, Maddocks ODK, Salmeron-Sanchez M, Machesky LM. The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis. Nature Metabolism. 2: 62-80. PMID 32694686 DOI: 10.1038/s42255-019-0159-z  0.367
2020 Whitelaw JA, Swaminathan K, Kage F, Machesky LM. The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration. Cells. 9. PMID 32646006 DOI: 10.3390/cells9071635  0.546
2020 Nikolaou S, Machesky LM. The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. The Journal of Pathology. 250: 612-623. PMID 32057095 DOI: 10.1002/path.5395  0.312
2019 Amato C, Thomason PA, Davidson AJ, Swaminathan K, Ismail S, Machesky LM, Insall RH. WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization. Current Biology : Cb. PMID 31786060 DOI: 10.1016/J.Cub.2019.10.036  0.33
2019 Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, Kalna G, Thomason P, Koh YWH, Norman JC, Insall RH, ... Machesky LM, et al. N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis. Developmental Cell. PMID 31668663 DOI: 10.1016/J.Devcel.2019.09.018  0.333
2019 Whitelaw JA, Lilla S, Paul NR, Fort L, Zanivan S, Machesky LM. CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors. Communicative & Integrative Biology. 12: 112-118. PMID 31413787 DOI: 10.1080/19420889.2019.1643665  0.339
2019 Francis S, Croft D, Schüttelkopf AW, Parry C, Pugliese A, Cameron K, Claydon S, Drysdale M, Gardner C, Gohlke A, Goodwin G, Gray CH, Konczal J, McDonald L, Mezna M, ... ... Machesky L, et al. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic & Medicinal Chemistry Letters. PMID 30773430 DOI: 10.1016/j.bmcl.2019.01.035  0.326
2019 Nikolaou S, Machesky LM. Invasion by Force: The C. elegans Anchor Cell Leads the Way. Developmental Cell. 48: 287-288. PMID 30753832 DOI: 10.1016/j.devcel.2019.01.024  0.406
2018 Papalazarou V, Salmeron-Sanchez M, Machesky LM. Tissue engineering the cancer microenvironment-challenges and opportunities. Biophysical Reviews. PMID 30406572 DOI: 10.1007/s12551-018-0466-8  0.362
2018 Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, ... ... Machesky LM, et al. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology. PMID 30250061 DOI: 10.1038/S41556-018-0198-9  0.393
2018 Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM. Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. The Journal of Pathology. PMID 29672847 DOI: 10.1002/path.5086  0.335
2017 Machesky L, Braga VMM. So far, yet so close: α-Catenin dimers help migrating cells get together. The Journal of Cell Biology. 216: 3437-3439. PMID 29051263 DOI: 10.1083/jcb.201709056  0.383
2017 Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ... ... Machesky LM, et al. Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. The Embo Journal. PMID 28694244 DOI: 10.15252/embj.201694912  0.403
2017 Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, ... ... Machesky LM, et al. Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin. Current Biology : Cb. PMID 28238662 DOI: 10.1016/J.Cub.2017.01.033  0.413
2016 Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH, Machesky LM. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell & Melanoma Research. PMID 27390154 DOI: 10.1111/Pcmr.12506  0.413
2016 García E, Ragazzini C, Yu X, Cuesta-García E, Bernardino de la Serna J, Zech T, Sarrió D, Machesky LM, Antón IM. WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Scientific Reports. 6: 23590. PMID 27009365 DOI: 10.1038/srep23590  0.329
2015 Rainero E, Howe JD, Caswell PT, Jamieson NB, Anderson K, Critchley DR, Machesky L, Norman JC. Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration. Cell Reports. PMID 25600874 DOI: 10.1016/J.Celrep.2014.12.037  0.47
2014 Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, et al. Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. Plos Biology. 12: e1001966. PMID 25313567 DOI: 10.1371/Journal.Pbio.1001966  0.42
2014 Ma Y, Machesky LM. Fascin1 in carcinomas: Its regulation and prognostic value. International Journal of Cancer. 137: 2534-44. PMID 25302416 DOI: 10.1002/ijc.29260  0.394
2014 García E, Machesky LM, Jones GE, Antón IM. WIP is necessary for matrix invasion by breast cancer cells. European Journal of Cell Biology. 93: 413-23. PMID 25169059 DOI: 10.1016/j.ejcb.2014.07.008  0.403
2014 Woodham EF, Machesky LM. Polarised cell migration: intrinsic and extrinsic drivers. Current Opinion in Cell Biology. 30: 25-32. PMID 24953729 DOI: 10.1016/j.ceb.2014.05.006  0.367
2014 Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, ... ... Machesky LM, et al. Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology. 146: 1386-96.e1-17. PMID 24462734 DOI: 10.1053/j.gastro.2014.01.046  0.35
2014 Tyrrell BJ, Neilson M, Insall RH, Machesky LM. Predicting cell shapes in melanomas. Pigment Cell & Melanoma Research. 27: 5-6. PMID 24118871 DOI: 10.1111/Pcmr.12176  0.362
2013 Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM. Fascin 1 is dispensable for developmental and tumour angiogenesis. Biology Open. 2: 1187-91. PMID 24244855 DOI: 10.1242/bio.20136031  0.38
2013 Sonego M, Gajendra S, Parsons M, Ma Y, Hobbs C, Zentar MP, Williams G, Machesky LM, Doherty P, Lalli G. Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12171-85. PMID 23884926 DOI: 10.1523/Jneurosci.0653-13.2013  0.362
2013 Schachtner H, Calaminus SD, Thomas SG, Machesky LM. Podosomes in adhesion, migration, mechanosensing and matrix remodeling. Cytoskeleton (Hoboken, N.J.). 70: 572-89. PMID 23804547 DOI: 10.1002/cm.21119  0.491
2013 Ma Y, Li A, Faller WJ, Libertini S, Fiorito F, Gillespie DA, Sansom OJ, Yamashiro S, Machesky LM. Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development (Cambridge, England). 140: 2203-11. PMID 23633513 DOI: 10.1242/dev.089789  0.419
2013 Park L, Thomason PA, Zech T, King JS, Veltman DM, Carnell M, Ura S, Machesky LM, Insall RH. Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell. 24: 169-81. PMID 23369714 DOI: 10.1016/J.Devcel.2012.12.014  0.373
2013 Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM. Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology : Cb. 23: 107-17. PMID 23273897 DOI: 10.1016/J.Cub.2012.11.059  0.397
2013 Li A, Machesky LM. Melanoblasts on the move: Rac1 sets the pace. Small Gtpases. 3: 115-9. PMID 22790200 DOI: 10.4161/sgtp.19494  0.451
2012 Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, ... ... Machesky LM, et al. N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. The Journal of Cell Biology. 199: 527-44. PMID 23091069 DOI: 10.1083/Jcb.201203025  0.411
2012 Zech T, Calaminus SD, Machesky LM. Actin on trafficking: could actin guide directed receptor transport? Cell Adhesion & Migration. 6: 476-81. PMID 23076144 DOI: 10.4161/cam.21373  0.346
2012 Spence HJ, Timpson P, Tang HR, Insall RH, Machesky LM. Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. The Biochemical Journal. 448: 35-42. PMID 22909346 DOI: 10.1042/Bj20112206  0.365
2012 Veltman DM, King JS, Machesky LM, Insall RH. SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods. The Journal of Cell Biology. 198: 501-8. PMID 22891261 DOI: 10.1083/Jcb.201205058  0.355
2012 García E, Jones GE, Machesky LM, Antón IM. WIP: WASP-interacting proteins at invadopodia and podosomes. European Journal of Cell Biology. 91: 869-77. PMID 22823953 DOI: 10.1016/j.ejcb.2012.06.002  0.536
2012 Maritzen T, Zech T, Schmidt MR, Krause E, Machesky LM, Haucke V. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex Proceedings of the National Academy of Sciences of the United States of America. 109: 10382-10387. PMID 22689987 DOI: 10.1073/pnas.1206468109  0.412
2012 Schachtner H, Li A, Stevenson D, Calaminus SD, Thomas SG, Watson SP, Sixt M, Wedlich-Soldner R, Strathdee D, Machesky LM. Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo. European Journal of Cell Biology. 91: 923-9. PMID 22658956 DOI: 10.1016/j.ejcb.2012.04.002  0.325
2012 Stevenson RP, Veltman D, Machesky LM. Actin-bundling proteins in cancer progression at a glance. Journal of Cell Science. 125: 1073-9. PMID 22492983 DOI: 10.1242/Jcs.093799  0.325
2012 Dawson JC, Bruche S, Spence HJ, Braga VM, Machesky LM. Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. Plos One. 7: e31141. PMID 22479308 DOI: 10.1371/journal.pone.0031141  0.465
2012 Yu X, Machesky LM. Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. Plos One. 7: e30605. PMID 22347388 DOI: 10.1371/journal.pone.0030605  0.563
2011 Zech T, Calaminus SD, Caswell P, Spence HJ, Carnell M, Insall RH, Norman J, Machesky LM. The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. Journal of Cell Science. 124: 3753-9. PMID 22114305 DOI: 10.1242/Jcs.080986  0.504
2011 Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell. 21: 722-34. PMID 21924960 DOI: 10.1016/J.Devcel.2011.07.008  0.507
2011 Machesky LM, Li A. Fascin: Invasive filopodia promoting metastasis. Communicative & Integrative Biology. 3: 263-70. PMID 20714410 DOI: 10.4161/cib.3.3.11556  0.455
2010 Scott RW, Hooper S, Crighton D, Li A, König I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. The Journal of Cell Biology. 191: 169-85. PMID 20876278 DOI: 10.1083/jcb.201002041  0.478
2010 Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, MacHesky LM, Anderson KI, Frame MC. A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity Current Biology. 20: 1086-1092. PMID 20493699 DOI: 10.1016/j.cub.2010.04.042  0.374
2010 Brooks SP, Coccia M, Tang HR, Kanuga N, Machesky LM, Bailly M, Cheetham ME, Hardcastle AJ. The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology. Human Molecular Genetics. 19: 2421-32. PMID 20332100 DOI: 10.1093/hmg/ddq125  0.385
2010 Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, König I, Anderson K, Machesky LM. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Current Biology : Cb. 20: 339-45. PMID 20137952 DOI: 10.1016/j.cub.2009.12.035  0.515
2009 Insall RH, Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Developmental Cell. 17: 310-22. PMID 19758556 DOI: 10.1016/J.Devcel.2009.08.012  0.388
2009 Machesky LM, Tang HR. Actin-based protrusions: promoters or inhibitors of cancer invasion? Cancer Cell. 16: 5-7. PMID 19573806 DOI: 10.1016/j.ccr.2009.06.009  0.423
2008 Johnston SA, Bramble JP, Yeung CL, Mendes PM, Machesky LM. Arp2/3 complex activity in filopodia of spreading cells. Bmc Cell Biology. 9: 65. PMID 19068115 DOI: 10.1186/1471-2121-9-65  0.482
2008 Zech T, Machesky L. Rab5 and rac team up in cell motility. Cell. 134: 18-20. PMID 18614005 DOI: 10.1016/j.cell.2008.06.039  0.432
2008 Machesky LM. Lamellipodia and filopodia in metastasis and invasion. Febs Letters. 582: 2102-11. PMID 18396168 DOI: 10.1016/j.febslet.2008.03.039  0.472
2008 Machesky L, Jurdic P, Hinz B. Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. Embo Reports. 9: 139-43. PMID 18202718 DOI: 10.1038/sj.embor.7401162  0.41
2007 Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hülskamp M. The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis Development. 134: 967-977. PMID 17267444 DOI: 10.1242/dev.02792  0.355
2006 Baldassarre M, Ayala I, Beznoussenko G, Giacchetti G, Machesky LM, Luini A, Buccione R. Actin dynamics at sites of extracellular matrix degradation. European Journal of Cell Biology. 85: 1217-31. PMID 17010475 DOI: 10.1016/J.Ejcb.2006.08.003  0.434
2006 Ten Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG. Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. The Biochemical Journal. 397: 39-45. PMID 16599904 DOI: 10.1042/BJ20051957  0.358
2006 Ardern H, Sandilands E, Machesky LM, Timpson P, Frame MC, Brunton VG. Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex Cell Motility and the Cytoskeleton. 63: 6-13. PMID 16317717 DOI: 10.1002/cm.20101  0.373
2005 Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Molecular and Cellular Biology. 25: 1680-95. PMID 15713627 DOI: 10.1128/Mcb.25.5.1680-1695.2005  0.325
2004 Unsworth KE, Way M, McNiven M, Machesky L, Holden DW. Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication Cellular Microbiology. 6: 1041-1055. PMID 15469433 DOI: 10.1111/j.1462-5822.2004.00417.x  0.404
2004 Insall RH, Machesky LM. Regulation of WASP: PIP2 Pipped by Toca-1? Cell. 118: 140-1. PMID 15260983 DOI: 10.1016/J.Cell.2004.07.005  0.401
2004 Vartiainen MK, Machesky LM. The WASP-Arp2/3 pathway: genetic insights. Current Opinion in Cell Biology. 16: 174-81. PMID 15196561 DOI: 10.1016/j.ceb.2004.02.004  0.39
2003 Launay S, Brown G, Machesky LM. Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells. Cell Motility and the Cytoskeleton. 54: 274-85. PMID 12601690 DOI: 10.1002/cm.10101  0.333
2003 Magdalena J, Millard TH, Etienne-Manneville S, Launay S, Warwick HK, Machesky LM. Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models. Molecular Biology of the Cell. 14: 670-84. PMID 12589062 DOI: 10.1091/mbc.e02-06-0345  0.463
2003 Magdalena J, Millard TH, Machesky LM. Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment. Journal of Cell Science. 116: 743-56. PMID 12538774 DOI: 10.1242/jcs.00288  0.381
2003 Anderson SI, Behrendt B, Machesky LM, Insall RH, Nash GB. Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton. 54: 135-46. PMID 12529859 DOI: 10.1002/Cm.10091  0.35
2003 Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. Cell Motility and the Cytoskeleton. 54: 81-90. PMID 12451597 DOI: 10.1002/cm.10087  0.321
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